Fluoridating remineralizing of enamel

The aim of this paper is to review the contemporary non-fluoridated systems available for remineralization therapy and ideas for their implementation into clinical practice.A search of articles from "Pubmed" and "Medline" with the keywords Remineralization-demineralization, Casein derivatives, Non-fluoridated remineralizing agents was conducted.Caseins are a heterogeneous family of proteins predominated by alpha 1 and 2 and b-caseins.CPPs are phosphorylated casein-derived peptides produced by tryptic digestion of casein.Sodium calciumphosphosilicate (bioactive glass) When bioactive glass comes in contact with saliva, it rapidly releases sodium, calcium, and phosphorous ions into the saliva that are available for remineralization of the tooth surface.The ions released form hydroxycarbonate apatite (HCA) directly.This could also control acid formation (buffering) in dental plaque, in turn reducing hydroxyapatite dissolution from tooth enamel.It can be incorporated into the pellicle in exchange for albumin, and thus inhibits the adherence of Streptrococcus mutans and Streptococcus sobrinus, causing both neutralization and enhancement of remineralization. CPP-ACP has been trademarked Recaldent and has been launched in sugarless chewing gum and confectionery.

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Experimental ACP composite has shown to efficiently establish mineral ion transfer throughout the body of the lesion and restore the mineral lost due to acid attack. It is also used in the Aegis product line, such as Aegis Pit and Fissure Sealant, produced by Bosworth.The goal of modern dentistry is to manage non-cavitated carious lesions non-invasively through remineralization in an attempt to prevent disease progression, and to improve strength, esthetics, and function of teeth.The emphasis currently is being given to new technologies for enamel remineralization which suggest the changes in the understanding of dental caries.Remineralization is defined as the process whereby calcium and phosphate ions are supplied from a source external to the tooth to promote ion deposition into crystal voids in demineralized enamel to produce net mineral gain.Fluoride is known to promote remineralization, but is dependent on calcium and phosphate ions from saliva to accomplish this.

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